약용작물학 (Medicinal Plants)

식물생장조절론 (Theory of Plant Growth Regulation)

채소원예학 (Vegetable Crops)

식물조직배양학 (Plant Tissue Culture)

○ 노인성질환 효능성분의 분석방법 및 인지기능 효능 검증

○ 항노화산업 지원을 위한 인프라구축 및 제품개발 - 인지기능개선 제품 개발

○ 천연물 신약후보물질의 개발 및 효력시험 연구

○ 활성추적분리법을 통한 천식 효능성분 탐색 및 구조 동정

○ 마늘로부터 천연물의 순수분리 , 구조동정 후 순수물질의 면역 , 항염증 , 함암 효과 검증

○ 맥문동으로부터 천연물의 순수분리 , 구조동정 후 순수물질 항당뇨 및 뇌질환억제 효과 검증

○ 항염증 , 당뇨 / 뇌질환 효능 천연물질의 탐색을 통한 천연물 신약 또는 식의약품화

○ 원예특작자원으로부터 생리활성물질의 순수분리 및 동정

○ HPLC, GC, LC/MS 및 NMR 등을 이용한 생리활성물질의 동정 및 양 측정에 의한 품질 비교

○ 불량환경 대응 수출딸기 재배기술 및 품질 평가기술 개발

2021 년

Eun-Gyeong Kim, Gwang-Hwan Ahn, Girim Park, Beunggu Son, Youngwhan Choi, Jumsoon Kang, Youngjae Lee, Byeong Il Je, Younghoon ParkTraits and Gene Expression Analysis of Early and Late Ripening Pollination Constant Non-Astringent Persimmon Fruits at Different Developmental Phases, 2021, Horticultural Science & Technology, 39(3)387 ~ 401

Joong Suk Jeon, He Mi Kang, Ju Ha Park, Jum Soon Kang, Yong Jae Lee, Young Hoon Park, Byoung Il Je, Sun Young Park, Young Whan Choi(Corresponding author), A comparative study on photo-protective and anti-melanogenic properties of different kadsura coccinea extracts, 2021, PLANTS-BASEL, 10(8)1633 ~ 1633

Su Jin Lee, Ji Eun Kim, Yun Ju Choi, Jeong Eun Gong, You Jeong Jin, Da Woon Lee, Young Whan Choi, and Dae Youn HwangAnti-Obesity Effect of alpha-Cubebenol Isolated from Schisandra chinensis in 3T3-L1 Adipocytes, 2021, BIOMOLECULES, 11(11)1650 ~ 1650

Ji-Eun Kim, Yun-Ju Choi, Su-Jin Lee, Jeong-Eun Gong, You-Jung Jin, So-Hae Park, Hee-Seob Lee, Young-Whan Choi, Jin-Tae Hong, Dae-Youn HwangLaxative Effects of Phlorotannins Derived from Ecklonia cava on Loperamide-Induced Constipation in SD Rats, 2021, MOLECULES, 26(23)7209 ~ 7209

2020 년
Sun Young Park, Zhengwei Cui, Beomjin Kim, Geuntae Park, Young-Whan Choi(Corresponding author), Treatment with gold nanoparticles using cudrania tricuspidata root extract induced downregulation of MMP-2/-9 and PLD1 and inhibited the invasiveness of human u87 glioblastoma cells, 2020, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(4)1282 ~ 1282

Lu Guo, Jum Soon Kang, Nam Jun Kang, Byoung Il Je, Yong Jae Lee, Young Hoon Park, Young Whan Choi (Corresponding author), Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway, 2020, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 686()108365 ~ 108365

Lu Guo, Jum Soon Kang, Young Hoon Park, Beong Il Je, Yong Jae Lee, Nam Jun Kang, Sun Young Park, Dae Youn Hwang and Young Whan Choi(Corresponding author), S-petasin inhibits lipid accumulation in oleic acid-induced HepG2 cells through activation of the AMPK signaling pathway, 2020, FOOD & FUNCTION, 11(6)5664 ~ 5673

Lu Guo, Ke Li, Jum Soon Kang, Nam Jun Kang, Beung Gu Son, Young Whan Choi(Corresponding author), Strawberry fermentation with Cordyceps militaris has anti-adipogenesis activity, 2020, FOOD BIOSCIENCE, 35()1 ~ 6S

Sun Young Park, Beomjin Kim, Zhengwei Cui, Geuntae Park, Young-Whan Choi(Corresponding author), Anti-metastatic effect of gold nanoparticle-conjugated maclura tricuspidata extract on human hepatocellular carcinoma cells, 2020, INTERNATIONAL JOURNAL OF NANOMEDICINE, 15()5317 ~ 5331

Sun Young Park, Min Hyun Cho, Mei Li, Ke Li, Geuntae Park, Young-Whan Choi(Corresponding author), Petatewalide B alleviates oxygen-glucose deprivation/reoxygenation-induced neuronal injury via activation of the AMPK/Nrf2 signaling pathway, 2020, MOLECULAR MEDICINE REPORTS, 22(1)239 ~ 246

Sun Young Park, Guo Lu, Beomjin Kim, Woo Chang Song, Geuntae Park, Young-Whan Choi(Corresponding author), A comparative study on physicochemical, photocatalytic, and biological properties of silver nanoparticles formed using extracts of different parts of Cudrania tricuspidata, 2020, NANOMATERIALS, 10(7)1 ~ 15

Dae-Gun Park, Da Jeong Kim, Bok Hee Woo, Hye Jung Kim, Young Whan Choi, Hae Ryoun Park, Isobutyrylshikonin has a potentially stronger cytotoxic effect in oral cancer cells than its analogue shikonin in vitro, 2020, ARCHIVES OF ORAL BIOLOGY, 116()12 ~ 25

Mi Rim Lee, Ji Eun Kim, Ji Won Park, Mi Ju Kang, Hyeon Jun Choi, Su Ji Bae, Young Whan Choi, Kyung Mi Kim, Jin Tae Hong, Dae Youn Hwang, Fermented mulberry (Morus alba) leaves suppress high fat diet-induced hepatic steatosis through amelioration of the inflammatory response and autophagy pathway, 2020, BMC COMPLEMENTARY MEDICINE AND THERAPIES, 20(1)283 ~ 300

Lu Guo, Jum Soon Kang, Nam Jun Kang, Young Whan Choi(Corresponding author), S-petasin induces apoptosis and inhibits cell migration through activation of p53 pathway signaling in melanoma B16F10 cells and A375 cells, 2020, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 692()1 ~ 6

Su Ji Bae, Ji Eun Kim, Yun Ju Choi, Su Jin Lee, Jeong Eun Gong, Young-Whan Choi, Dae Youn Hwang, Novel Function of α-Cubebenoate Derived from Schisandra chinensis as Lipogenesis Inhibitor, Lipolysis Stimulator and Inflammasome Suppressor, 2020, MOLECULES, 25(21)4995 ~ 4995

Mi Rim Lee, Ji Eun Kim, Jin Ju Park, Jun Young Choi, Bo Ram Song, Young Whan Choi, Dong-Seob Kim, Kyung Mi Kim, Hyun Keun Song, Dae Youn Hwang, Protective role of fermented mulberry leave extract in LPS-induced inflammation and autophagy of RAW264.7 macrophage cells, 2020, MOLECULAR MEDICINE REPORTS, 22(6)4685 ~ 4695

Lu Guo, Jum Soon Kang, Young Hoon Park, Beong Il Je, Dae Youn Hwang, Woo Hong Joo, Y(Corresponding author), Fermentation of mulberry leaves with Cordyceps militaris enhanced anti-adipogenesis activity in 3T3-L1 cells through down-regulation of PPAR-gamma pathway signaling, 2020, ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE, 13(12)557 ~ 557

Gyu-Bin Lee, Jung-Eun Lee, Jae-Hyung Lee, Yong-Jae Lee, Young-Hoon Park, Young-Whan Choi, Beung-Gu Son, Nam-Jun Kang, Byoung Il Je & Jum-soon Kang, Phytohormone profiles of 'Seolhyang' and 'Maehyang' strawberry fruits during ripening, 2020, HORTICULTURE ENVIRONMENT AND BIOTECHNOLOGY, 61(2)229 ~ 239

Daen Kim, Beunggu Son, Youngwhan Choi, Jumsoon Kang, Yongjae Lee, Beungil Je, Younghoon Park, Quantitative analysis of water-soluble vitamins and polyphenolic compounds in tomato varieties (Solanum lycopersicum L.), 2020, Journal of Plant Biotechnology, 47(1)78 ~ 89

Mi Rim Lee, Ji Eun Kim, Jun Young Choi, Jin Ju Park, Hye Ryeong Kim, Bo Ram Song, Young Whan Choi, Kyung Mi Kim, Hyunkeun Song, Dae Youn Hwang, Anti-obesity effect in high-fat-diet-induced obese C57BL/6 mice: Study of a novel extract from mulberry (Morus alba) leaves fermented with Cordyceps militaris, 2019, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 17(3)2185 ~ 2193

Lu Guo, Ke Li, Zheng Wei Cui, Jum Soon Kang, Beung Gu Son, Young Whan Choi(Corresponding author), iS-Petasin isolated from Petasites japonicus exerts anti-adipogenic activity in the 3T3-L1 cell line by inhibiting PPAR-γ pathway signaling, 2019, FOOD & FUNCTION, 10(7)4396 ~ 4406

2018 년

Sun Young Park, Min Hyun Choi, Mei Li, Ke Li, Geuntae Park, Young-Whan Choi(Corresponding author), AMPK/Nrf2 signaling is involved in the anti-neuroinflarnmatory action of Petatewalide B from Petasites japonicus against lipopolysaccharides in microglia, 2018, IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 40(3)232 ~ 241

Bong-Hae Cho, Yun-Hoa Jung, Da Jeong Kim, Bok Hee Woo, Ji Eun Jung, Ji Hye Lee, Young Whan Choi, Hae Ryoun Park, Acetylshikonin suppresses invasion of Porphyromonas gingivalis-infected YD10B oral cancer cells by modulating the interleukin-8/matrix metalloproteinase axis, 2018, MOLECULAR MEDICINE REPORTS, 17(2)2327 ~ 2334

Sun Young Park, Min Hyun Choi, Geuntae Park, Young-Whan Choi(Corresponding author), Petasites japonicus bakkenolide B inhibits lipopolysaccharide-induced pro-inflammatory cytokines via AMPK/Nrf2 induction in microglia, 2018, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 41(3)1683 ~ 1692

Sun Young Park, Young-Whan Choi, Geuntae Park, Nrf2-mediated neuroprotection against oxygen-glucose deprivation/reperfusion injury by emodin via AMPK-dependent inhibition of GSK-3 beta, 2018, JOURNAL OF PHARMACY AND PHARMACOLOGY, 70(4)525 ~ 535

Mi Rim Lee, Ji Eun Kim, Jun Young Choi, Jin Ju Park, Hye Ryeong Kim, Bo Ram Song, Ji Won Park, Mi Ju Kang, Young Whan Choi, Kyung Mi Kim, Dae Youn Hwang, Morusin Functions as a Lipogenesis Inhibitor as Well as a Lipolysis Stimulator in Differentiated 3T3-L1 and Primary Adipocytes, 2018, MOLECULES, 23(8)0 ~ 0

Sirichat Kaowinn, Chutima Kaewpiboon, Ji Eun Kim, Mi Rim Lee, Dae Youn Hwang, Young Whan Choi, Hong Won Kim, Jin Kyoon Park, Kyung-Mo Song, Nam Hyouck Lee, Jin-Soo Maeng, Young-Hwa Chun, N-Benzyl-N-methyl-dodecan-1-amine, a novel compound from garlic, exerts anti-cancer effects on human A549 lung cancer cells overexpressing cancer upregulated gene (CUG)2, 2018, EUROPEAN JOURNAL OF PHARMACOLOGY, 841()19 ~ 27

Ji Eun Kim, Mi Rim Lee, Jin Ju Park, Jun Young Choi, Bo Ram Song, Hong Joo Son, Young Whan Choi, Kyung Mi Kim, Jin Tae Hong, Dae Youn Hwang, Quercetin promotes gastrointestinal motility and mucin secretion in loperamide-induced constipation of SD rats through regulation of the mAChRs downstream signal, 2018, PHARMACEUTICAL BIOLOGY, 56(1)309 ~ 317

Byeong Hyeok Ye, Eun jung Kim, Seung Eun Baek, Young Whan Choi, So youn Park, Chi Dae Kim, α-Isocubebene modulates vascular tone by inhibiting myosin light chain phosphorylation in murine thoracic aorta, 2018, The Korean Journal of Physiology & Pharmacology, 22(4)437 ~ 445

2017 년

Sung Hwa Song, Seong Mi Choi, Ji Eun Kim, Ji Eun Sung, Hyun Ah Lee, Yung Hyun Choi, Chang Joon Bae, Young Whan Choi, Dae Youn Hwang, alpha-Isocubebenol alleviates scopolamine-induced cognitive impairment by repressing acetylcholinesterase activity, 2017, NEUROSCIENCE LETTERS, 638()121 ~ 128

Sun Young Lee, Sung Min Ahn, Ziyu Wang, Young Whan Choi, Hwa Kyoung Shin, Byung Tae Choi, Neuroprotective effects of 2,3,5,4′-tetrahydoxystilbene-2-O-β-D-glucoside from Polygonum multiflorum against glutamate-induced oxidative toxicity in HT22 cells, 2017, JOURNAL OF ETHNOPHARMACOLOGY, 195()64 ~ 70

Ji Eun Kim, Eun Kyoung Koh, Sung Hwa Song, Ji Eun Sung, Hyun Ah Lee, Hong Gu Lee, Young Whan Choi, Dae Youn Hwang, Effects of five candidate laxatives derived from Liriope platyphylla on the 5-HT receptor signaling pathway in three cell types present in the transverse colon, 2017, MOLECULAR MEDICINE REPORTS, 15(1)431 ~ 441

Min A Jang, Seung Jin Lee, Seung Eun Baek, So Youn Park, Young Whan Choi, Chi Dae Kim, α-Iso-Cubebene inhibits PDGF-induced vascular smooth muscle cell proliferation by suppressing osteopontin expression, 2017, PLOS ONE, 12(1)e0170699 ~ e0170699

So-Hye Hong, Mei Li, Eui-Bae Jeung, Geun-Shik Lee, Eui-Ju Hong, Young-Whan Choi, Beum-Soo An, Therapeutic effects of Schisandra chinensis on the hyperprolactinemia in rat, 2017, INTERNATIONAL JOURNAL OF ONCOLOGY, 50(4)1448 ~ 1454

Sun Young Park, Mei Ling Jin, Nam Jun Kang, Geuntae Park, Young-Whan Choi(Corresponding author), Anti-inflammatory effects of novel polygonum multiflorum compound via inhibiting NF-kappa B/MAPK and upregulating the Nrf2 pathways in LPS-stimulated microglia, 2017, NEUROSCIENCE LETTERS, 651()43 ~ 51

Jin-Woo Jeong, Jongsik Kim, Eun Ok Choi, Da Hye Kwon, Gyu Min Kong, Il-Whan Choi, Bum Hoi Kim, Gi-Young Kim, Ki Won Lee, Ki Young Kim, Sung Goo Kim, Young Whan Choi, Su Hyun Hong, Cheol Park, Yung Hyun Choi, SCHISANDRAE FRUCTUS ETHANOL EXTRACT AMELIORATES INFLAMMATORY RESPONSES AND ARTICULAR CARTILAGE DAMAGE IN MONOSODIUM IODOACETATE-INDUCED OSTEOARTHRITIS IN RATS, 2017, Excli Journal, 16()265 ~ 277

Jaemin Jung, Joonyup Kim, Bingkui Jin, Youngmi Choi, Chang Oh Hong, Hyun Ho Lee, Youngwhan Choi, Jumsoon Kang, and Younghoon Park, Characterization of the Lsi1 Homologs in Cucurbita moschata and C. ficifolia for Breeding of Stock Cultivars Used for Bloomless Cucumber Production, 2017, Horticultural Science & Technology, 35(3)333 ~ 343

Min Jung Ko, Ramesha H Jayaramaiah, Ravi Gupta, So Wun Kim, Jae Uk An, Wang Jziyu, Mae Li, Nam Jun Kang, Kwang-Pyo Hong, Jum-Soon Kang, Sun Tae Kim, Young Whan Choi(Corresponding author), Evaluation of Bioactive Compounds in Strawberry Fruits by a Targeted Metabolomic Approach, 2017, Horticultural Science & Technology, 35(6)805 ~ 819

2016 년

Jin-Woo Jeong, Hye Hyeon Lee, Ki Won Lee, Ki Young Kim, Sung Goo Kim, Su Hyun Hong, Gi-Young Kim, Cheol Park, Ho Kyoung Kim, Young Whan Choi(Corresponding author) and Yung Hyun CHOi. 2016. Mori folium inhibits interleukin-1 β -induced expression of matrix metalloproteinases and inflammatory mediators by suppressing the activation of NF- κ B andp38 MAPK in SW1353 human chondrocytes. International Journal of Molecular Medicine 37: 452 - 460, 2016

Young-Whan Choi(1st author), Kyoung-Pil Lee, Jung-Min Kim, Saeromi Kang, Soo-Jin Park, Jung-Min Lee, Hyung Ryong Moon, Jee H Jung, Young-Geun Lee, Dong-Soon Im. 2016. Petatewalide B, a novel compound from Petasites japonicus with anti-allergic activity. J Ethnopharmacol 178:17-24

Hee Ra Park, Ju Yeon Kim, Yujeong Lee, Hye Jeong Chun, Young Whan Choi , Hwa Kyoung Shin, Byung Tae Choi, Cheol Min Kim, Jaewon Lee. 2016. PMC-12, a traditional herbal medicine, enhances learning memory and hippocampal neurogenesis in mice. Neurosci Lett 23;617:254-63.

Sung Min Ahn, Ha Neui Kim, Yu Ri Kim, Young Whan Choi, Cheol Min Kim, Hwa Kyoung Shin, Byung Tae Choi, Emodin from Polygonum multiflorum ameliorates oxidative toxicity in HT22 cells and deficits in photothrombotic ischemia, 2016, JOURNAL OF ETHNOPHARMACOLOGY, 188:13 ~ 20

Sun Young Park, Mei Ling Jin, Seon Yeong Chae, Min Jung Ko, Yung Hyun Choi, Geuntae Park, Young-Whan Choi(Corresponding author), Novel compound from Polygonum multiflorum inhibits inflammatory response in LPS-stimulated microglia by upregulating AMPK/Nrf2 pathways, 2016, NEUROCHEMISTRY INTERNATIONAL, 100:21 ~ 29

Hyun-Kyoung Yoon, Hyun-Kyu An, Min Jung Ko, Kyoung-Sook Kim, Seo-Won Mun, Dong-Hyun Kim, Cheol Min Kim, Cheorl-Ho Kim, Young Whan Choi(Corresponding author) and Young-Choon Lee, Upregulation of human ST8 Sia VI (α2,8-sialyltransferase) gene expression by physcion in SK-N-BE(2)-C human neuroblastoma cells, 2016, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 17(8)1 ~ 13

Da Jeong Kim, Ji Hye Lee, Hae Ryoun Park, Young Whan Choi(Corresponding author) , Acetylshikonin inhibits growth of oral squamous cell carcinoma by inducing apoptosis, 2016, ARCHIVES OF ORAL BIOLOGY, 70:149 ~ 157

Sun Young Park, Mei Ling Jin, Ziyu Wang, Geuntae Park, Young-Whan Choi(Corresponding author), 2,3,4 ',5-tetrahydroxystilbene-2-O-beta-D-glucoside exerts anti-inflammatory effects on lipopolysaccharide-stimulated microglia by inhibiting NF-kappa B and activating AMPK/Nrf2 pathways, 2016, FOOD AND CHEMICAL TOXICOLOGY, 97:159 ~ 167

Sun Young Park, Mei Ling Jin, Min Jung Ko, Geuntae Park, Young-Whan Choi(Corresponding author), Anti-neuroinflammatory Effect of Emodin in LPS-Stimulated Microglia: Involvement of AMPK/Nrf2 Activation, 2016, NEUROCHEMICAL RESEARCH, 41(11)2981 ~ 2992

2015 년

Kyoung-Pil Lee, Saeromi Kang, Min-Soo Noh, Soo-Jin Park, Jung-Min Kim, Hae Young Chung, Nam Kyung Je, Young-Geun Lee, Young-Whan Choi , and Dong-Soon Im. 2015. Therapeutic Effects of S-Petasin on Disease Models of Asthma and Peritonitis. Biomol Ther 23(1), 45-52

Shin-Ji Park, Mei Ling Jin, Hyun-Kyu An, Kyoung-Sook Kim, Min Jung Ko, Cheol Min Kim, Young Whan Choi (Corresponding author), Young-Choon Lee (Corresponding author). 2015. 1. 3. Emodin induces neurite outgrowth through PI3 K/Akt/GSK-3 β -mediated signaling pathways in Neuro2a cells. Neuroscience Letters 588C : 101-107.

Sun Young Park, Won Jung Jung, Jum Soon Kang, Cheol-Min Kim, Geuntae Park, and Young-Whan Choi (Corresponding author) . 2015. Neuroprotective effects of α -iso-cubebene against glutamate-induced damage in the HT22 hippocampal neuronal cell line. International Journal of Molecular Medicine 35(2): 525-532.

Chunja Nam, Jae-Sik Hwang, Myoung-Jun Kim, Young Whan Choi, Kyoung-Goo Han, Jong-Koo Kang. 2015. Single- and Repeat-dose Oral Toxicity Studies of Lithospermum erythrorhizon Extract in Dogs. Toxicological Research 31(1):77-88 .

Byeong Hyeok Ye, Seung Jin Lee, Young Whan Choi , So Youn Park and Chi Dae Kim. 2015. Preventive effect of gomisin J from Schisandra chinensis on angiotensin II-induced hypertension via an increased nitric oxide bioavailability. Hypertens Res 38(3):169-77.

Hyung Bum Seo, Bo Kyung Kang, Ji Hyun Kim, Young Whan Choi , Jin Woo Hong, Byung Tae Choi, Hwa Kyoung Shin. 2015 May 27. Partially purified components of Uncaria sinensis attenuate blood brain barrier disruption after ischemic brain injury in mice. BMC Complement Altern Med 2015 27: 15:157.

Min Young Park, Yeon Suk Jung, Jung Hwa Park, Young Whan Choi , Jaewon Lee, Cheol Min Kim, Jin Ung Baek, Byung Tae Choi, and Hwa Kyoung Shin. 2015. PMC-12, a Prescription of Traditional Korean Medicine, Improves Amyloid ??-Induced Cognitive Deficits through Modulation of Neuroinflammation. Evidence-Based Complementary and Alternative Medicine. 2015. 1-10.

Sung Min Ahn, Yu Ri Kim, Ha Neui Kim, Young Whan Choi , Jae Won Lee, Cheol Min Kim, Jin Ung Baek, Hwa Kyoung Shin, Byung Tae Choi. 2015. Neuroprotection and spatial memory enhancement of four herbal mixture extract in HT22 hippocampal cells and a mouse model of focal cerebral ischemia. BMC Complement Altern Med 5:202.

Minsoo Kook, Sung Kyun Lee, Sang Doo Kim, Ha Young Lee, Jae Sam Hwang, Young Whan Choi ( Corresponding authors. Young Whan Choi (Corresponding author ) , and Yoe-Sik Bae. 2015. Anti-septic activity of α -cubebenoate isolated from Schisandra chinensis. BMB Rep 48(6):336-341

Sung Kyun Lee, Yoo Jung Park, Min Jung Ko, Ziyu Wang, Ha Young Lee, Young Whan Choi (Corresponding author) , and Yoe-Sik Bae. 2015. A novel natural compound from garlic ( Allium sativum L.) with therapeutic effects against experimental polymicrobial sepsis. Biochemical and Biophysical Research Communications 464 : 774-779.

Sun Young Park, Yung Hyun Choi, Geuntae Park, Young-Whan Choi (Corresponding author) . 2015. 9. Neuroprotective effects of α -iso-cubebenol on glutamate-induced neurotoxicity. Environ Toxicol Pharmacol 40(2):549-56

Kyoung-Pil Lee, Saeromi Kang, Soo-Jin Park, Jung-Min Kim, Jung-Min Lee, Ae-Yeon Lee, Hae-Young Chung, Young-Whan Choi , Young-Geun Lee, Dong-Soon Im. 2015. 9. Anti-allergic effect of α -cubebenoate isolated from Schisandra chinensis using in vivo and in vitro experiments. J Ethnopharmacol 4;173:361-9.

Bo Kyung Kang, Mi Kyoung Kim, So Young Kim, Seung Jin Lee, Young Whan Choi, Byung Tae Choi, Hwa Kyoung Shin. 2015. 10. Anti-Neuroinflammatory Effects of Uncaria sinensis in LPS-Stimulated BV2 Microglia Cells and Focal Cerebral Ischemic Mice. Am J Chin Med 43(6):1099-115.

Chung-Tack Han, Myoung-Jun Kim, Seol-Hee Moon, Yu-Rim Jeon, Jae-Sik Hwang, Chunja Nam, Chong-Woo Park, Sun-Ho Lee, Jae-Bum Na, Chan-Sung Park, Hee-Won Park, Jung-Min Lee, Ho-Song Jang, Sun-Hee Park, Kyoung-Goo Han, Young Whan Choi , Hye-Yeong Lee, Jong-Koo Kang. 2015. 12. Acute and 28-Day Subacute Toxicity Studies of Hexane Extracts of the Roots of Lithospermum erythrorhizon in Sprague-Dawley Rats. Toxicol Res 31(4):403-14

Jin-Woo Jeong, Hye Hyeon Lee, Eun-Ok Choi, Ki Won Lee, Ki Young Kim, Sung Goo Kim, Su Hyun Hong, Gi-Young Kim, Cheol Park, Ho Kyoung Kim, Young Whan Choi , and Yung Hyun Choi. 2015. 10. Schisandrae Fructus Inhibits IL-1 β -Induced Matrix Metalloproteinases and Inflammatory Mediators Production in SW1353 Human Chondrocytes by Suppressing NF- κ B and MAPK Activation. Hypertens Res 38(3):169-77.

2014 년

Sun Young Park, Tae Gyeong Park, Sang-Joon Lee, Yoe-Sik Bae, Min J. Ko and Young-Whan Choi (Corresponding author). 2014. α -Iso-cubebenol inhibits inflammation-mediated neurotoxicity and amyloid beta 1-42 fibril-induced microglial activation. Journal of Pharmacy and Pharmacology 66(1), 93 ? 105

Ji Yeon Jang, Young Whan Choi (These authors contributed equally to this work) , Ha Neui Kim, Yu Ri Kim, Jin Woo Hong, Dong Won Bae, Se Jin Park, Hwa Kyoung Shin, Byung Tae Choi. 2014. Neuroprotective effects of a novel single compound 1-Methoxyoctadecan-1-ol isolated from Uncaria sinensis in primary cortical neurons and a photothrombotic ischemia model. PLOS one. 9(1) : e85322.

Sun Young Park, Yoe-Sik Bae, Min Jung Ko, Sang-Joon Lee and Young-Whan Choi (Corresponding author) . 2014. Comparison of anti-inflammatory potential of four different dibenzocyclooctadiene lignans in microglia; action via activation of PKA and Nrf-2 signaling and inhibition of MAPK/STAT/NF- κ B pathways. Molecular Nutrition & Food Research Mol. Nutr. Food Res. 58, 738 ? 748.

Soo Vin Lee, Kyung Ha Choi, Young Whan Choi , Jin Woo Hong, Jin Ung Back, Byung Tae Choi and Hwa Kyoung Shin. 2014. Hexane extracts of Polygonum multiflorum improve tissue and functional outcome following focal cerebral ischemia in mice. Molecular Medicine Reports 9: 1415-1421,

Sun Young Park, Rajasekar Seetharaman, Min Jung Ko, Do Yeon Kim, Tae Hoon Kim, Moo Kyoung Yoon, Jung Ho Kwak, Sang Joon Lee, Yoe Sik Bae, Young Whan Choi (Corresponding author). 2014. Ethyl linoleate from garlic attenuates lipopolysaccharide-induced pro-inflammatory cytokine production by inducing heme oxygenase-1 in RAW264.7 cells. International Immunopharmacology 19(2) 253 ? 261.

Saeromi Kang, Kyoung-Pil Lee, Soo-Jin Park, Dae-Young Noh, Jung-Min Kim, Hyung Ryong Moon, Young-Geun Lee, Young-Whan Choi (Corresponding author) , Dong-Soon Im. 2014. Identification of a novel anti-inflammatory compound, α -cubebenoate from Schisandra chinensis . Journal of Ethnopharmacology 153(2014) 242 ? 249.

Nagaiya Ravichandran, Gopal Suresh, Balasubramanian Ramesh, Ramar Manikandan, Young Whan Choi , and Ganesan Vijaiyan Siva. 2014. Fisetin modulates mitochondrial enzymes and apoptotic signals in benzo(a)pyrene-induced lung cancer. Mol Cell Biochem (2014) 390:225 ? 234. Mol Cell Biochem. 390(1-2):225-34.

Cheol Park, Sejin Park, Yoon Ho Chung, Gi-Young Kim, Young Whan Choi , Byung Woo Kim and Yung Hyun Choi. 2014. Induction of apoptosis by a hexane extract of aged black garlic inthe human leukemic U937 cells. Nutrition Research and Practice 2014;8(2):132-137.

Rajasekar Seetharaman, Sun Young Park, Moo Kyoung Yoon, Jung Ho Kwak, Beung Gu Son,Young Hoon Park, Jum Soon Kang, Young Jae Lee, Yung Hyun Choi, Yoe Sik Bae, and Young Whan Choi (Corresponding author) . 2014. Heme Oxygenase-1-mediated anti-inflammatory effect of a novel garlic compound in RAW264.7 murine macrophages. Hort. Environ. Biotechnol. 55(2):148-157.

Jeong Moon, Sang Seok Koh, Waraporn Malilas, Il-Rae Cho, Chutima Kaewpiboon, Sirichat Kaowinn, Keesook Lee, Byung Hak Jhun, Young Whan Choi , Young-Hwa Chung. 2014. Acetylshikonin induces apoptosis of hepatitis B virus X protein-expressing human hepatocellular carcinoma cells via endoplasmic reticulum stress. Eur J Pharmacol 2014 Jul 24;735:132-40.

Sun Young Park, Beung Gu Son, Young Hoon Park, Cheol-Min Kim, Geuntae Park, and Young-Whan Choi (Corresponding author) . 2014. The neuroprotective effects of a-iso-cubebene on dopaminergic cell death: Involvement of CREB/Nrf2 signaling. Neurochemical Research 39:1759 ? 1766

Ye Jin Han, Ju Hui Je, So Hyoung Kim, Sung Min Ahn, Ha Neui Kim, Yu Ri Kim, Young Whan Choi , Hwa Kyoung Shin, and Byung Tae Choi. 2014. Gastrodia elata shows neuroprotective effects via activation of PI3K signaling against oxidative glutamate toxicity in HT22 cells. The American Journal of Chinese Medicine 42(4): 1007 ? 1019.

Sun Young Park, Do Yeon Kim, Jong-koo Kang, Geuntae Park, Young-Whan Choi (Corresponding author) . 2014. Involvement of activation of the Nrf2/ARE pathway in protection against 6-OHDA-induced SH-SY5Y cell death by a-iso-cubebenol. NeuroToxicology 44, 160 ? 168.

Young-Soon Kang, Min-Ho Han, Su-Hyun Hong, Cheol Park, Hye-Jin Hwang, Byung Woo Kim, Kim Ho Kyoung, Young Whan Choi , Cheol Min Kim, Yung Hyun Choi. 2014. Anti-inflammatory effects of Schisandra chinensis (Turcz.) Baill fruit through the inactivation of Nuclear Factor- κ B and Mitogen-activated Protein Kinases signaling pathways in lipopolysaccharide stimulated Murine Macrophages. Journal of Cancer Prevention 19(4) 279-287.

2013 년

Ji Yeon Jang, Ha Neui Kim, Yu Ri Kim, Young Whan Choi , Yung Hyun Choi, Jun Hyuk Lee, Hwa Kyoung Shin, Byung Tae Choi. 2013. Hexane extract from Polygonum multiflorum attenuates glutamate-induced apoptosis in primary cultured cortical neurons. Journal of Ethnopharmacology 145 (2013) 261 ? 268. J Ethnopharmacol. 145(1):261-8.

Young Su Jung, Sung Kyun Lee, Chang Youp Ok, Eun Jung Cho, Joon Seong Park, Young Whan Choi (Corresponding authors) , and Yoe-Sik Bae. 2013. Role of CXCR2 on the immune modulating activity of α -iso-cubebenol a natural compound isolated from the Schisandra chinensis fruit. Biochemical and Biophysical Research Communications 431 (3) (2013) 433-436

In Sik Hwang, Jee Eun Kim, Yong Ju Lee, Moon Hwa Kwak, Young Hwan Choi , Byeong Cheol Kang, Jin Tae Hong and Dae Youn Hwang. 2013. Protective effects of gomisin A isolated from Schisandra chinensis against CCl 4 -induced hepatic and renal injury. International Journal of Molecular Medicine 31: 888-898,

Ki-Hyung Kim, Jin Kyeong Park, Young-Whan Choi , Youn-Han Kim, Eun Na Lee, Ja-Rang Lee, Heui-Soo Kim, Sun-Yong Baek, Bong-Seon Kim, Kyu-Sup Lee, Sik Yoon .2013. Hexane extract of aged black garlic reduces cell proliferation and attenuates the expression of ICAM-1 and VCAM ? 1 in TNF- α -activated human endometrial stromal cells. International Journal of Molecular Medicine 32(1):67-78.

Kyoung-Pil Lee, Saeromi Kang, Soo-Jin Park, Young-Whan Choi , Young-Geun Lee, Dong-Soon Im. 2013. Anti-allergic and anti-inflammatory effects of bakkenolide B isolated from Petasites japonicus leaves. Journal of Ethnopharmacology 148 (2013): 890 ? 894.

So Ra Kim, Yu Ri Jung, Hye Jin An, Dae Hyun Kim, Eun Ji Jang, Yeon Ja Choi, Kyoung Mi Moon, Min Hi Park, Chan Hum Park, Ki Wung Chung, Ha Ram Bae, Yung Whan Choi , Nam Deuk Kim, Hae Young Chung. 2013. Anti-Wrinkle and Anti-Inflammatory Effects of Active Garlic Components and the Inhibition of MMPs via NF- κ B Signaling. PLoS One. 2013 Sep 16;8(9):e73877

Sun Young Park, Se Jin Park, Tae Gyeong Park, Seetharaman Rajasekar, Sang-Joon Lee, Young-Whan Choi (Corresponding author) . 2013. Schizandrin C exerts anti-neuroinflammatory effects by upregulating phase II 2 detoxifying/antioxidant enzymes in microglia, International Immunopharmacology 17 (2013) 415 ? 426

Sun Young Park, Se Jin Park, Nan Jeong Park, Woo Hong Joo, Sang-Joon Lee, and Young-Whan Choi (Corresponding author) . 2013. α -iso-cubebene exerts neuroprotective effects in amyloid beta stimulated microglia activation. Neuroscience Letters. 143-148.

Ha Neui Kim, Yu Ri Kim, Ji Yeon Jang, Young Whan Choi , Jin Ung Baek, Jin Woo Hong, Yung Hyun Choi, Hwa Kyoung Shin, and Byung Tae Choi. 2013. Neuroprotective effects of Polygonum multiflorum extract against glutamate-induced oxidative toxicity in HT22 hippocampal cells. Journal of Ethnopharmacology 150(1), 108-115.

○ 오미자로부터 추출한 alpha-iso-cubebene 화합물을 유효성분으로 함유하는 항염증 질환에 대한 예방 및 치료제 . 2008.

○ 리그난 계열의 칼슘 유리 및 세포의 이동 촉진제 , 및 이를 포함하는 조직 재생 , 상처치료 , 또는 면역 질환의 예방 또는 치료용 조성물 . 2008.

○ 오미자로부터 추출한 신규한 α -iso-cubebenol 화합물 . 2008.

○ 오미자 종자로부터 리그난의 추출방법 . 2009.

○ 알파 - 이소 - 쿠베베놀을 포함하는 항염증 조성물 . 2009.

○ 파속류의 잔류농약 분석을 위한 전처리로서 황화합물 제거 방법 . 2010.

○ 에틸 리노레이트를 유효성분으로 포함하는 염증 예방 및 치료용 약학적 조성물 . 2010.

○ 맥문동 추출물 , 이의 분획물 , 또는 이로부터 분리한 화합물을 유효성분으로 포함하는 항염증 활성을 가지는 조성물 . 2010.

○ 맥문동 추출물을 유효성분으로 포함하는 신경퇴행성 질환의 치료 및 예방용 약학적 조성물 . 2010.

○ 오미자로부터 추출한 신규한 알파 - 이소 - 쿠베벤 화합물을 유효성분으로 하는 면역질 . 2011.

○ 결장암 , 흑색종 , 위암 , 간암 또는 유방암의 예방 또는 치료용 약학 조성물 . 2011.

○ 마늘 추출물의 항전이효과 . 2011.

○ 효모로 발효된 마늘의 헥산 추출물을 포함하는 혈액종양의 예방 또는 치료용 의약 조성물 . 2012.

○ 뇌혈관 질환의 예방 또는 치료용 의약 조성물 및 건강기능식품 . 2012.

○ 흑마늘 추출물을 함유하는 사람 자궁내막증 예방 및 치료를 위한 약제학적 조성물 . 2012.

○ 지치 추출물을 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물 . 2012.

○ 알파 - 이소 - 쿠베벤을 유효성분으로 포함하는 감염성 및 염증성 질환의 예방 또는 치료용 조성물 . 2012.

○ 오미자로부터 분리한 신규한 α - ｃｕｂｅｂｅｎａｔｅ 화합물 . 2012..

○ 알파 ― 이소 ― 쿠베베놀을 유효성분으로 포함하는 감염성 및 염증성 질환의 예방 또는 치료용 조성물 . 2012.

○ 머위로부터 순수분리한 신규한 Petatewalide B 화합물 . 2012.

○ 항암 활성을 향상시킨 신품종 마늘 . 2012.

○ 마늘 유래 우라실을 유효성분으로 함유하는 주름 개선용 조성물 . 2013.

○ 전 알파 - 이소 - 쿠베벤 또는 알파 - 이소 - 쿠베베놀을 유효성분으로 포함하는 감염성 및 염증성 질환의 예방 또는 치료용 조성물 . 2013.

○ 고미신 J 를 유효성분으로 포함하는 고혈압의 예방 또는 치료용 조성물 . 2013.

○ N- 벤질 -N- 메틸데칸 -1- 아민을 유효성분으로 포함하는 암 예방 또는 치료용 조성물 및 상기 화합물의 분리방법 . 2013.

○ α - 쿠베베노에이트를 유효성분으로 함유하는 알러지 예방 또는 치료용 조성물 . 2014.

○ 알파 - 이소 - 쿠베베네를유효성분으로포함하는신경질환의예방또는치료용조성물 . 2014.

○ 오미자유래알파 - 큐베베노이트를유효성분으로포함하는패혈증또는패혈증쇼크의예방또는치료용조성물 . 2014.

○ Ethyl linoleate from garlic attenuates lipopolysaccharide-induced pro-inflammatory cytokinin by heme oxygenase-1 in marine macrophages

○ Inhibition of TNF-a-induced reactive oxygen species generation, cell adhesion molecule expression and NF-kB activation by 5-hydroxymethylfurfural in human umbilical vein endothelial cells

○  Anti-inflammatory Activity of Novel Compound of Schisandra Chinensis Against Porphyromonas gingivalis

○ T he Mechanism of vasodilation induced by Gomisin J from Schisandra Chinensis in rat thoracic aorta

○  Induction of Apoptosis by Hexane Extract of Aged Black Garlic in Chemoresistant Ovarian Cancer Cells

○  The Hexane extract of garlic inhibits cell growth of human ovarian cancer cells by inducing apotosis

○  마늘 발효추출물 처리에 의한 U937 인체 혈구암 세포의 Apoptosis 유도

○  머위 (Petasitus japonicus Max) 추출물의 항암효과 및 신물질의 구조동정

○  Anti-allergic and anti-inflammatory effects of bakkenolide B isolated Petasites Japonicus

○  a-iso-cubebene is neuroprotective against microglial neuroinflammation induced by amyloid

○  a-iso-cubebenol inhibits inflammation-medicated neurotoxicity and amyloid beta 1-42 fibrils-induced microglia activation

○  Anticnacer activity-guided purification from Allium sativum L. and structure elucidation of a novel GDP compound against colorectal cancer

○ Isolation of a noval bakkenolides from Petasitus japonicus and its seasional change in leaf, petiole, and rhizome

○ Anti-hypertensive effects of gomisin J from Schisandra chinensis in angiotensin Ⅱ-induced hypertensive mice

○ Gomisin J from schisandra chinensis prevents angiotensin II induced hypertension in mice

○ Antiasthma and anti-peritonitis effects of O-methylthioangeloylsencathenone

○ Identification of a novel anti-inflammatory compound from Schisandra chinensis

○ 오미자로부터 약리 활성물질인 리그난의 대량분리를 통한 산업화

○ 친환경 채소